生物活性

PR-619是一种细胞可渗透、可逆、广谱的去双基化酶抑制剂。

Targets

Target	Value
JOSD2	EC50: 1.17μM
SENP6core	EC50: 2.37μM
UCH-L3	EC50: 2.95μM
USP4	EC50: 3.93μM
USP8	EC50: 4.90μM
DEN1	EC50: 4.98μM
USP20	EC50: 5.10μM
USP28	EC50: 6.24μM
USP7	EC50: 6.86μM
USP2core	EC50: 7.20μM
USP15	EC50: 8.23μM
USP5	EC50: 8.61μM
USP47	EC50: 8.87μM
UCH-L5	EC50: 9.26μM
UCH-L1	EC50: 12.8μM
Plpro	EC50: 14.2μM
PLA2	EC50: >50μM
Calpain1	EC50: >50μM
CT-L	EC50: >50μM
CathepsinD	EC50: >50μM
MMP13	EC50: >50μM
Trypsin	EC50: >50μM

化学数据

目录号	A13190
作用机制	Inhibitor (抑制剂)
M. Wt	223.28
Formula	C7H5N5S2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2645-32-1
Synonyms	PR619, PR 619
SMILES	C1=C(C(=NC(=C1SC#N)N)N)SC#N

溶解度

In vitro	DMSO	42 mg/mL (188.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	44.79 mL	223.93 mL	447.87 mL
0.5 mM	8.96 mL	44.79 mL	89.57 mL
1 mM	4.48 mL	22.39 mL	44.79 mL
5 mM	0.9 mL	4.48 mL	8.96 mL

*The above data is based on the productmolecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.