| CAS NO: | 74058-71-2 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 345.6 |
| Cas No. | 74058-71-2 |
| Formula | C23H39NO |
| Synonyms | N-Benzylhexadecanamide |
| Solubility | ≤2mg/ml in organic solvent ethanol |
| Chemical Name | N-(phenylmethyl)-hexadecanamide |
| Canonical SMILES | O=C(CCCCCCCCCCCCCCC)NCC1=CC=CC=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
N-Benzylpalmitamide is an inhibitor of fatty acid amide hydrolase (FAAH) [1].
The fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH is involved in degrading the fatty acid amide family of endogenous signaling lipids, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to is a member of amidase signature (AS) family. The FAAH integrates into cell membranes and terminates fatty acid amide signaling in vivo [2]. Genetic mutations in FAAH may constitute important risk factors for problem drug use and support a potential link between functional abnormalities in the endogenous cannabinoid system and drug abuse and dependence [3].
N-Benzylpalmitamide was a long-chain fatty acid amide isolated from the maca (L. meyenii) plant and was structurally related to cannabinoids. N-Benzylpalmitamide was a moderate inhibitor of FAAH and inhibited 44% activity of FAAH at 500 μM [1].
References:
[1] Wu H, Kelley C J, Pino-Figueroa A, et al. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5188-5197.
[2] Deutsch D G, Ueda N, Yamamoto S. The fatty acid amide hydrolase (FAAH)[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002, 66(2): 201-210.
[3] Sipe J C, Chiang K, Gerber A L, et al. A missense mutation in human fatty acid amide hydrolase associated with problem drug use[J]. Proceedings of the National Academy of Sciences, 2002, 99(12): 8394-8399.
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