| CAS NO: | 6217-54-5 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Physical Appearance | Colorless oil |
| Storage | Store at -20°C |
| M.Wt | 328.49 |
| Cas No. | 6217-54-5 |
| Formula | C22H32O2 |
| Solubility | insoluble in H2O; ≥44.9 mg/mL in DMSO; ≥50.7 mg/mL in EtOH |
| Chemical Name | (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid |
| Canonical SMILES | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Docosahexaenoic acid is an omega-3 fatty acid [1].
Docosahexaenoic acid, one of the main structural lipids in the mammalian brain, plays crucial roles in the development and function of brain neurons. Deficiency of docosahexaenoic acid induces loss of discriminative learning ability [1].
In neural stem cells (NSCs), docosahexaenoic acid is effective in a narrow range (i.e. 2 ~ 10 μM), and higher concentrations induced neuronal cell death. Docosahexaenoic acid at the concentration of 10 μM significantly increased the number of Tuj1(+) neurons, and the newborn neurons in the docosahexaenoic acid group were morphologically more mature than those in the control. Furthermore, docosahexaenoic acid administration inhibited the proliferation of NSCs in the early stages of differentiation, and prevented cell death of differentiating NSCs [1].
Administration of docosahexaenoic acid (300 mg/kg/day, p.o.) substantially increased the number of 5-bromo-2’-deoxyuridine(+)/NeuN(+) newborn neurons in the granule cell layer of the dentate gyrus in adult rats, which suggested that dietary docosahexaenoic acid promoted hippocampal neurogenesis in adult rats [1].
Reference:
[1]. Kawakita E, Hashimoto M, Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience, 2006, 139(3): 991-997.
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