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Alprostadil

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

745-65-3

包装与价格：

半岛bd体育手机客户端介绍

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	354.48
Cas No.	745-65-3
Formula	C20H34O5
Solubility	insoluble in H2O; ≥13.4 mg/mL in DMSO; ≥47.1 mg/mL in EtOH
Chemical Name	7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Canonical SMILES	CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

Prostaglandin E1 (Alprostadil) is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties.

Cell experiment:[1]
Cell lines	Human umbilical vein endothelial cells (HUVECs)
Reaction Conditions	0 ~ 10 μM alprostadil
Applications	Alprostadil (1 nM ~ 10 μM; 48 h) concentration-dependently reduced HUVEC proliferation (up to 100% inhibition) in the presence of 20 ng/mL vascular endothelial growth factor (VEGF), with an IC50 of 400 nM. Alprostadil (0.01 ~ 10 μM; 6 h) also inhibited VEGF-induced HUVEC migration in a concentration dependent manner, with an IC50 of 500 nM.
Animal experiment:[1]
Animal models	Female C57/bl6 mice, 6 ~ 8 weeks of age
Dosage form	20 ng Administered subcutaneously for 4 days
Applications	Alprostadil treatment (20 ng/animal/day; 4 days) significantly inhibited the fibroblast growth factor (FGF)-induced angiogenesis in mice. Alprostadil could be useful for diseases that require anti-angiogenic therapy, such as diabetic retinopathy and solid tumors.
Note	The technical data provided above is for reference only.
	References: 1. Cattaneo MG, Pola S, Dehò V, et al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. British Journal of Pharmacology, 2003, 138(2): 377-385.