| CAS NO: | 747-36-4 |
| 包装 | 价格(元) |
| 10mM (in 1mL H2O) | 电议 |
| 50mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 433.95 |
| Cas No. | 747-36-4 |
| Formula | C18H28ClN3O5S |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥17.6 mg/mL in H2O |
| Chemical Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid |
| Canonical SMILES | CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Hydroxychloroquine Sulfate is a synthetic quinine derivative commonly used as an antimalarial drug.1 It is also useful in managing systemic lupus erythematosus, rheumatoid arthritis, and other diseases. Also acts as an inhibitor of autophagy and toll-like receptor 7/9(TLR7/9)[1-3].
Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands[4].
Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling[4].
References:
[1]. Ben-Zvi I, Kivity S, Langevitz P, et al. Hydroxychloroquine: From Malaria to Autoimmunity. Clin. Rev. Allergy Immunol, 2012, 42(2): 145-153.
[2]. Yildirim-Toruner C, Diamond B. Current and novel therapeutics in the treatment of systemic lupus erythematosus. Journal of Allergy and Clinical Immunology, 2011, 127(2): 303-312.
[3]. Swierkot J, and Szechinski J. Methotrexate in rheumatoid arthritis. Pharmacol. Rep, 2006, 58(4): 473-492.
[4]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol, 2014, 85(3): 429-40.
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