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IL-17A,human recombinant protein
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
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包装与价格：
包装 价格(元)
25ug 电议
1mg 电议

半岛bd体育手机客户端 介绍

描述

Gene ID: 3605 Accession #: Q16552
Alternate Names: Human IL-17A, IL-17A, IL17A, IL 17 A, h-IL-17A, rh-IL-17A, recombinant human IL-17A, recombinant IL-17, IL, interluekin.
Source: Escherichia Coli. M.Wt: 31.0 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation: Sterile filtered and lyophilized with no additives.
Solubility: Reconstitute in H2O to a concentration of 0.1-1.0 μg/μl. The solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

资料参考

Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases and stimulates the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as the production of nitric oxide (NO). IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNF-α and IL-6, and induces production of the neutrophil chemoattractants IL-8, CXCL1 and CXCL6. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders.

IL-17A is a homodimer of two 136 amino acid chains. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant IL-17 is a 31 kDa disulfide-linked homodier of two 136 amino acid polypeptide chains.

生物活性

Determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts.
ED50 < 2 ng/ml.
Specific activity > 5*105units/mg.
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