描述
| Gene ID: |
839 |
Accession #: |
P55212 |
| Alternate Names: |
Active Human Caspase-6, Active Caspase-6, Caspase-6 Enzyme, Recombinant caspase-6, human caspase-6, human caspases, active caspases. |
| Source: |
Escherichia Coli. |
M.Wt: |
(18 kDa) and small (11 kDa) |
| Appearance: |
Lyophilized powder |
Storage: |
Store at -70℃ |
| Formulation: |
Lyophilized powder |
| Solubility: |
Reconstitute to 1 unit per μl in PBS containing 15% glycerol. |
| Shipping Condition: |
Gel pack. |
Handling: |
Centrifuge the vial prior to opening. |
| Usage: |
For Research Use Only! Not to be used in humans. |
资料参考
Caspase-6 (also know as Mch2) belongs to the caspase-family of cysteine proteases. Like other caspases, caspase-6 exists in cells as an inactive proenzyme. Sequential activation of caspases plays a key role in the execution-phase of cell apoptosis. Caspases undergo proteolytic processing at conserved aspartic residues and produce two subunits, large (18 kDa) one and small (11 kDa) one. The two subunits dimerize to form the active enzyme. Active caspase-6 has been reported involving in the proteolysis of poly ADP-ribose polymerase (PARP), PARP is involved in DNA repair and henomic maintenance. The function of this protein in the caspase activation cascade is thought as a downstream enzyme and is processed by caspases 7, 8 and 10. Caspase-6 can also undergo self-processing without other caspases. The recombinant active human caspase-6 was expressed in E. coli.
生物活性
| Specific activity |
> 13000 units/mg. |
m.cnreagent.com
