| CAS NO: | 62-99-7 |
| 包装: | 5mg |
| 市场价: | 1330元 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 304.42 |
| Cas No. | 62-99-7 |
| Formula | C19H28O3 |
| Solubility | ≤1mg/ml in acetonitrile;1mg/ml in ethanol;1mg/ml in methanol |
| Chemical Name | (6R,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| Canonical SMILES | C[C@]12[C@]([H])([C@@]3(C[C@H](C4=CC(CC[C@@]4([C@]3(CC2)[H])C)=O)O)[H])CC[C@@H]1O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens[1]. They mediate the metabolism of xenobiotics and certain intrinsic biotin, including steroid hormones[2].
6β-hydroxytestosterone is the main metabolite produced from testosterone through the action of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed by testosterone[2,3].
References:
[1]. Cooper B W, Cho T M, Thompson P M, et al. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicological Sciences, 2008, 103(2): 268-277.
[2]. Draper A J, Madan A, Smith K, et al. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Drug Metabolism and Disposition, 1998, 26(4): 299-304.
[3]. Capdevila J H, Karara A, Waxman D J, et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. The Journal of Biological Chemisty, 1990, 265: 10865-10871.
m.cnreagent.com
