| CAS NO: | 51833-78-4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 899 |
| Cas No. | 51833-78-4 |
| Formula | C41H62N12O11 |
| Synonyms | Asp-Arg-Val-Tyr-Ile-His-Pro |
| Solubility | insoluble in EtOH; ≥48.5 mg/mL in H2O; ≥89.9 mg/mL in DMSO |
| Chemical Name | Angiotensin (1-7) |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Ang(1-7)的氨基酸序列为H - Asp - Arg - Val - Tyr - Ile - His - Pro – OH，是血管紧张素I或血管紧张素Ⅱ在内肽酶或羧基肽酶作用下产生的内源性肽片段[1]。
最初发现的Ang(1-7)主要在心血管和肾脏中发挥功能，Ang(1-7)与血管紧张素Ⅱ类似，在不同器官和组织广泛分布，发挥作用。这些作用是由Mas介导的，可以反向调节血管紧张素Ⅱ造成的大部分有害影响。Ang(1-7)/Mas的相互作用调节不同的信号通路，如PI3K（磷酸肌醇3-激酶）/AKT和ERK（胞外信号调节激酶）途径，下游效应因子如NO、FOXO1和COX-2（环氧化酶-2）参与其中。通过这些机制，Ang(1-7)能够改善一些病理状况，包括器官的纤维化和炎症，如肺、肝和肾脏[2]。
此外，这种七肽对代谢具有积极的效果，增加葡萄糖摄取和脂肪分解，同时降低胰岛素抗性和血脂异常。除了影响学习和记忆外，在缺血性中风中，Angiotensin (1-7)能够提高脑保护。Ang(1-7)可以作用于生殖系统，具有增强排卵以及精子和类固醇合成的作用。Ang(1-7) 能够抑制细胞增殖和血管生成，被认为是一种潜在的抗癌治疗手段[2]。
Fig. 1: Formula of Angiotensin (1-7)
Fig. 2: Cascade of the processing of angiotensin peptides and their interaction with AT1 and AT1-7 receptor systems.
参考文献：
1. Santos et al (2000)Angiotensin-(1-7): an update. Regul.Pept. 91 45.
2. Danielle G. P., Thiago V., Robson A. S.Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)
| Cell experiment:[1] | |
Cell lines |
Rat kidney NRK-52E cells |
Reaction Conditions |
100 nM angiotensin (1-7) |
Applications |
Angiotensin (1-7) abrogated the methylglyoxal albumin-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells. Moreover, the inhibitory effects of angiotensin (1-7) on myofibroblast transition could be reversed by the angiotensin (1-7) receptor antagonist A779 (10 μM). |
| Animal experiment:[2] | |
Animal models |
Male and female BALB/c mice (1:1 ratio, 6 ~ 10 weeks old, mean weight 20 g) |
Dosage form |
0.01, 0.06, 0.1, 0.3 and 1 mg/kg Once daily by intraperitoneal route |
Applications |
Daily angiotensin (1-7) treatment (0.01 ~ 0.06 mg/kg) resulted in significant amelioration of dextran sulfate sodium-induced colitis, whereas daily administration of A779 significantly worsened features of colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt was also reduced by angiotensin (1-7) treatment. |
Note |
The technical data provided above is for reference only. |
References: 1. Alzayadneh EM, Chappell MC. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cellular Signalling, 2014, 26(12): 3027-3035. 2. Khajah MA, Fateel MM, Ananthalakshmi KV, et al. Anti-inflammatory action of angiotensin 1-7 in experimental colitis. PLoS One, 2016, 11(3): e0150861. |
|
m.cnreagent.com
