| CAS NO: | 1210-83-9 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 218.3 |
| Cas No. | 1210-83-9 |
| Formula | C12H14N2O2 |
| Synonyms | N-Acetyl-5-hydroxytryptamine,NAS |
| Solubility | insoluble in H2O; ≥11.5 mg/mL in EtOH; ≥33.65 mg/mL in DMSO |
| Chemical Name | N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-acetamide |
| Canonical SMILES | OC1=CC=C(NC=C2CCNC(C)=O)C2=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
N-Acetylserotonin is an agonist at the melatonin receptors MT1, MT2, and MT3.
A melatonin receptor is a G protein-coupled receptor binding melatonin. Three types of melatonin receptor have been identified. The MT1 and MT2 receptor subtypes are in humans and other mammals, whereas an additional melatonin receptor subtype MT3 has been identified in amphibia and birds.
In vitro: N-Acetylserotonin, a precursor of melatonin, was acetylated from serotonin by arylalkylamine Nacetyltransferase (AANAT). N-Acetylserotonin was found to be able to swiftly activate TrkB in a circadian manner. N-Acetylserotonin also exhibited antidepressant effect in a TrkB-dependent manner. In additioin, N-acetylserotonin could rapidly activate TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner. Moreover, N-acetylserotonin, but not melatonin, showed a robust antidepressant-like behavioral effect in a TrkB-dependent way [1].
In vivo: Animal study found that in BDNF knockout mice the administration of N-acetylserotonin could activate TrkB. Moreover, the endogenous TrkB was activated in wild-type C3H/f+/+ mice but not in AANAT-mutated C57BL/6J mice, in a circadian rhythm. In addition, TrkB activation was found to be high at night in the dark and low during the day [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Jang, S. W.,Liu, X.,Pradoldej, S., et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proceedings of the National Academy of Sciences of the United States of America 107(8), 3876-3881 (2010).
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