| CAS NO: | 90536-15-5 |
| 包装 | 价格(元) |
| 5mg (solution) | 电议 |
| 10mg (solution) | 电议 |
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 182.2 |
| Cas No. | 90536-15-5 |
| Formula | C9H10O2S |
| Solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| Chemical Name | α-mercapto-benzenepropanoic acid |
| Canonical SMILES | OC(C(S)CC1=CC=CC=C1)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
PD 145305 is an inactive analog of PD 150606, a potent and selective calpains inhibitor [1].
Calpain is a class of cytosolic cysteine protease that is activated by elevated intracellular calcium. Overactivation of calpain has been implicated in the pathophysiology of several degenerative conditions, including stroke, myocardial ischemia, neuromuscular degeneration, and cataract formation [1].
PD 145305 is an inactive analog of PD 150606, a potent and selective calpains inhibitor. PD 150606, an alpha-mercaptoacrylate derivative, inhibited μ-calpain and m-calpain with Ki values of 0.21 and 0.37 μM, respectively. PD 145305 was inactive at concentrations up to 500 μM. In human leukemic Molt-4 cells, PD150606 inhibited a-spectrin proteolysis in a dose-dependent way and virtually eliminated the formation of the 145-kDa fragment at 10 μM, whereas PD145305 did not attenuate a-spectrin breakdown product formation. In fetal rat cerebrocortical cultures subjected to a combination of hypoxia and hypoglycemia, PD150606 significantly inhibited the release of lactate dehydrogenase, whereas PD145305 was ineffective. PD150606, but not PD145305, was found to make cerebral glutamatergic neurons more resistant to hypoxic/hypoglycemic challenge [1].
Reference:
[1]. Wang KK, Nath R, Posner A, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.
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