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Necrostatin-7

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

351062-08-3

包装与价格：

半岛bd体育手机客户端介绍

Necrotatin-7 (Nec-7) 是一种有效的坏死性凋亡抑制剂，EC50 为 10.6 μM。 Necrotatin-7 不抑制重组 RIP1 激酶。

Cas No.	351062-08-3
别名	5-[[3-(4-氟苯基)-1H-吡唑-4-基]亚甲基]-2-亚氨基-3-(2-噻唑基)-4-噻唑烷酮,Nec-7
Canonical SMILES	O=C(N(C1=NC=CS1)C(S/2)=N)C2=C\C3=CN([H])N=C3C4=CC=C(F)C=C4
分子式	C₁₆H₁₀FN₅OS₂
分子量	371.4
溶解度	DMSO: Soluble,Ethanol: Soluble
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.