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Perindoprilat
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Perindoprilat图片
CAS NO: 95153-31-4
包装与价格：
包装 价格(元)
500μg 电议
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
Perindoprilat (S 9780) 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50 值为 1.5 至 3.2 nM。
Cas No. 95153-31-4
别名 培哚普利,S-9780
化学名 (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
Canonical SMILES [H][C@]12[C@](N(C([C@H](C)N[C@@H](CCC)C(O)=O)=O)[C@H](C(O)=O)C2)([H])CCCC1
分子式 C17H28N2O5
分子量 340.4
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. [1] Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[1][2][3]

Reference:
[1]. Wang, J.g., Pimenta, E., and Chwallek, F. Comparative review of the blood pressure-lowering and cardiovascular benefits of telmisartan and perindopril. Vascular Health and Risk Management 10, 189-200 (2014).
[2]. Sennesael, J., Ali, A., Sweny, P., et al. The pharmacokinetics of perindopril and its effects of serum angiotensin converting enzyme activity in hypertensive patients with chronic renal failure. Br.J.Clin.Pharmac. 33, 93-99 (1992).
[3]. Parker, E., Aarons, L., Rowland, M., et al. The pharmacokinetics of perindoprilat in normal volunteers and patients: Influence of age and disease state. European Journal of Pharmaceutical Sciences 26(1), 104-113 (2005).
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