| CAS NO: | 3317-61-1 |
| 包装: | 50mg |
| 市场价: | 980元 |
| Physical Appearance | A colorless oil |
| Storage | Store at -20°C |
| M.Wt | 113.16 |
| Cas No. | 3317-61-1 |
| Formula | C6H11NO |
| Solubility | ≥11.3 mg/mL in DMSO; ≥55.9 mg/mL in H2O; ≥65.8 mg/mL in EtOH |
| Chemical Name | 2,2-dimethyl-3,4-dihydro-2H-pyrrole 1-oxide |
| Canonical SMILES | [O-][N+]1=CCCC1(C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
DMPO is a kind of water soluble nitric oxide spin trap, which allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR).[1]
It has a high reaction rate constant for superoxide and hydroxyl radicals, and distinguishes simultaneously among a variety of important biologically generated free radicals.[1][2]
In vitro, It was demonstrated in red blood cells and in hamster V79 cells that the DMPO spin adducts of ·O2–and ·OH are metabolized very rapidly so that even if formed, they may not be detected in many experiments with cells.[1]
In vivo, when DMPO perfused the heart at 100 μm/L, it attenuated the development of reperfusion arrhythmias during the first 10 min of reperfusion and improved the functional recovery of the heart during reperfusion. Without treatment, 55% of hearts showed irreversible ventricular fibrillation, and this was completely prevented by DMPO, due to its function of traping·O2–and ·OH radicals.[2]
References:
[1] Samuni A1, Samuni A, Swartz HM. The cellular-induced decay of DMPO spin adducts of ·O2–and ·OH. Free Radic Biol Med. 1989; 6(2):179-83.
[2] Tosaki A1, Blasig IE, Pali T, et al. Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts. Free Radic Biol Med. 1990; 8 (4):363-72.
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