| 包装 | 价格(元) |
| 10ug | 电议 |
| 100ug | 电议 |
| Gene ID: | 3791 | Accession #: | P35968 |
| Alternate Names: | VEGFR-2, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1. | ||
| Source: | Insect cells. | M.Wt: | 116 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20℃ |
| Formulation: | Lyophilized from a sterile solution containing 25 mM MES pH 5.5 and 100 mM NaCl. | ||
| Solubility: | Reconstitute in sterile water to a concentration not less than 0.1 mg/ml. This solution can then be stored at 4℃ for 2-7 days. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA) then store at -20℃. Avoid freeze-thaw cycles. | ||
| Shipping Condition: | Blue ice. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Vascular endothelial growth factor receptor 2 (VEGFR-2) belongs to the family of receptor tyrosine kinases (RTKs) and is almost exclusively restricted to endothelial cells. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. VEGFR-2 has seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 mediates mitogenic activity in endothelial cells, which leading to their proliferation. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
Recombinant human VEGFR-2 is produced in baculovirus as a monomeric, glycosylated, polypeptide and having a total molecular mass of 116 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding. The VEGFR-2 is purified by proprietary chromatographic techniques.
| Determined by its ability to abolish the binding of iodinated VEGF to solid surfaces or cell surfaces receptors. | ||||||
| ED50 | 10.0 ng/ml. | |||||
| Specific activity | 100,000IU/mg. | |||||
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