化学性质
| Storage |
Store at -20°C |
| M.Wt |
559.61 |
| Cas No. |
1443763-60-7 |
| Formula |
C29H26FN5O4S |
| Synonyms |
Empesertib |
| Solubility |
≥35 mg/mL in DMSO |
| Chemical Name |
(R)-2-(4-fluorophenyl)-N-(4-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)propanamide |
| Canonical SMILES |
FC1=CC=C([C@H](C(NC2=CC=C(C3=CN4N=C(N=C4C=C3)NC5=CC=C(S(=O)(C)=O)C=C5OC)C=C2)=O)C)C=C1 |
| 运输条件 |
蓝冰运输或根据您的需求运输。 |
| 一般建议 |
为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次半岛bd体育手机客户端 溶解度各有差异，仅做参考。若实验所需浓度过大至半岛bd体育手机客户端 溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
BAY1161909 is an oral bioavailable selective inhibitor of serine / threonine monopolar spindle 1 (Mps1) kinase with potential antitumor activity. After administration, BAY1161909 binds and inhibits the activity of Mps1, leading to inactivation of spindle assembly checkpoints (SAC), accelerated mitosis, chromosomal misalignment, chromosomal mispolymerization, unstable mitotic checkpoint complexes and increased aneuploidy . This leads to the induction of cell death in cancer cells that overexpress Mps1.
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