| CAS NO: | 226395-93-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 226395-93-3 |
| Canonical SMILES | FC(F)(F)OC1=CC=C(OC2=CC=C(S(C3(C(NO)=O)CCN(CCOC)CC3)(=O)=O)C=C2)C=C1.Cl |
| 分子式 | C22H25F3N2O7S ? HCl |
| 分子量 | 555 |
| 溶解度 | DMSO: 100 mM,Water: 100 mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | SD 2590 is an inhibitor of matrix metalloproteinase-2 (MMP-2), -3, -8, -9, and -13 (IC50s = <0.1, 28.7, 1.7, 0.18, and <0.1 nM, respectively).1 It is selective for these MMPs over MMP-1 and MMP-7 (IC50s = >10,000 and 7,000 nM, respectively). SD 2590 (10 mg/kg per day) inhibits dilation of the left ventricle in rats following myocardial infarction (MI) compared to MI vehicle control animals. |1. Becker, D.P., Barta, T.E., Bedell, L.J., et al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J. Med. Chem. 53(18), 6653-6680 (2010). |
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