Biotin-PEG-azide (MW 600) 是基于 PEG 结构的 PROTAC linker,可以用来制备 PROTAC。
Cas No. |
956494-20-5 |
分子量 |
600.00(Average) |
储存条件 |
Store at -20°C |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Biotin-PEG-azide (MW 600) is a PEG-basedPROTAC linkercan be used in the synthesis of PROTAC[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1]. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |