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AR420626
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AR420626图片
CAS NO: 1798310-55-0
包装与价格：
包装 价格(元)
500μg 电议
1mg 电议
5mg 电议
10mg 电议

半岛bd体育手机客户端 介绍
Cas No. 1798310-55-0
化学名 N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxamide
Canonical SMILES ClC1=CC(NC(C2=C(C)NC(CCCC3=O)=C3C2C4=CC=CO4)=O)=C(Cl)C=C1
分子式 C21H18Cl2N2O3
分子量 417.3
溶解度 5mg/mL in DMSO, 2mg/mL in DMF
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
半岛bd体育手机客户端 描述

Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.[1] AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.[2] At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.[3]

Reference:
[1]. Inoue, D., Tsujimoto, G., and Kimura, I. Regulation of energy homeostasis by GPR41. Front.Endocrinol.(Lausanne) 5, 1-3 (2014).
[2]. Engelstoft, M.S., Park, W.m., Sakata, I., et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol.Metab. 2(4), 376-392 (2013).
[3]. Nohr, M.K., Pedersen, M.H., Gille, A., et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology 154(10), 3552-3564 (2013).
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