您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 半岛bd体育手机客户端 库> 5-O-Demethylnobiletin
立即咨询
咨询类型:
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
5-O-Demethylnobiletin
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-O-Demethylnobiletin图片
CAS NO: 2174-59-6
包装与价格:
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素,一种从黄芪中分离出的多甲氧基黄酮,是 5-LOX 的直接抑制剂 (IC50=0.1 μM),不影响 COX-2 的表达。5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素具有抗炎活性,抑制大鼠中性粒细胞中白三烯 B (4)(LTB4) 的形成和人嗜中性粒细胞中弹性蛋白酶的释放,IC50 值为0.35 μM.5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素通过激活 MAPK/ERK-,PKC- 和 PKA 依赖性信号传导途径促进神经发生。
Cas No. 2174-59-6
别名 去甲基川陈皮素,5-Demethylnobiletin
Canonical SMILES O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13
分子式 C20H20O8
分子量 388.37
溶解度 Soluble in DMSO
储存条件 4°C, protect from light
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2]. IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1]

[1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.

Baidu
map