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PKUMDL WQ 2201

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

592474-91-4

包装与价格：

半岛bd体育手机客户端介绍

Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

Cas No.	592474-91-4
Canonical SMILES	CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S
分子式	C₁₅H₁₄ClN₃O₃S
分子量	351.81
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model. Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046