| CAS NO: | 17372-87-1 |
| 包装: | 100mg |
| 市场价: | 389元 |
| Cas No. | 17372-87-1 |
| 别名 | 水溶伊红,Acid Red 87 |
| 化学名 | sodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate |
| Canonical SMILES | BrC1=C([O-])C(Br)=C2C(C(C3=CC=CC=C3C([O-])=O)=C4C=C(Br)C(C(Br)=C4O2)=O)=C1.[Na+].[Na+] |
| 分子式 | C20H6Br4Na2O5 |
| 分子量 | 691.85 |
| 溶解度 | ≥ 69.2mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | IC50: 0.78 and 1.41 μM for Hmt1p and PRMT1, respectively AMI5 is a non-selective protein methyltransferase inhibitor. Post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. The enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription. In vitro: AMI-5 has been identified as a competitive inhibitor of SAM binding and had been shown to inhibit not only PRMTs but also lysine methylation by the Set7 and disruptor of telomeric silencing 1-like (DOT1L) MTases in vitro. Both AMI-5 and its analog AMI-1 have been used as lead compounds for the development of novel MTase-specific inhibitors. Moreover, it was found that AMI-5 could inhibit Set7 in vitro and decrease H3K4m1 in vascular endothelial cells. [1]. In vivo: Currently, there is no animal study reported. Clinical trial: Up to now, AMI-5 is still in the preclinical development stage. Reference: |
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