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Gamma-glutamylcysteine(TFA)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Gamma-glutamylcysteine(TFA)图片
CAS NO: 283159-88-6
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA))是谷胱甘肽 (GSH) 合成的中间体，一种作为抗氧化酶谷胱甘肽过氧化物酶 (GPx) 的必需辅助因子的二肽。 Gamma-glutamylcysteine (TFA) 上调抗炎细胞因子 IL-10 的水平，降低促炎细胞因子 (TNF-α，IL-6 和 IL-1β) 的水平，并减弱在寡聚 Aβ40 处理的星形胶质细胞中金属蛋白酶活性的变化。
Cas No. 283159-88-6
别名 γ-Glutamylcysteine TFA
Canonical SMILES SC[C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O.OC(C(F)(F)F)=O
分子式 C10H15F3N2O7S
分子量 364.3
溶解度 Soluble in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1]. IL-10 IL-6 IL-1β TNF-α

[1]. Braidy N, et al. The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. Front Aging Neurosci. 2019 Aug 8;11:177.
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