GSK2983559 - 半岛电竞官方网址

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GSK2983559

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1579965-12-0

包装与价格：

半岛bd体育手机客户端介绍

GSK2983559 (compound 3) 是一种高效、特异性的，口服有效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂，在体内和人类炎症性肠病外植体样本中，具有良好的阻断多种促炎细胞因子反应活性。

Cas No.	1579965-12-0
Canonical SMILES	CC(C)(C)S(C(C(OCCOP(O)([O-])=O)=CC1=NC=N2)=CC1=C2NC3=CC(N=CS4)=C4C=C3)(=O)=O.[H]O[H].[H]O[H].[H]O[H].[Ca+2].[1/2]
分子式	C₂₁H₂₈CaN₄O₁₀PS₂
分子量	611.61
溶解度	DMF: slightly soluble,DMSO: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	GSK2983559 (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor, which has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1]. RIP2[1] [1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.