TrimethoprimN-oxide(Trimethoprim1-N-oxide)属于人尿代谢物。TrimethoprimN-oxide是通过氧化嘧啶环中的氮原子生成的。TrimethoprimN-oxide主要由CYP1A2在人肝微粒体中形成。
Cas No. |
27653-68-5 |
别名 |
Trimethoprim 1-N-oxide |
Canonical SMILES |
NC1=NC(N)=C(CC2=CC(OC)=C(OC)C(OC)=C2)C=[N+]1[O-] |
分子式 |
C14H18N4O4 |
分子量 |
306.32 |
储存条件 |
Store at -20℃ |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes[1]. [1]. Goldman JL, et al. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep;43(9):1372-80. |