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Cyclic ADP-Ribose(ammonium salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclic ADP-Ribose(ammonium salt)图片
包装与价格：
包装 价格(元)
500μg 电议
1mg 电议

半岛bd体育手机客户端 介绍
别名 cADP-Ribose；cADPR
化学名 1-β-D-ribofuranosyl-adenosine 5'-(trihydrogen diphosphate), intramol. P',5''-ester, diammonium salt
Canonical SMILES N=C1C2=C(N3C=N2)N=CN1[C@@]4([H])[C@H](O)[C@H](O)[C@](COP(OP(OC[C@@]5([H])O[C@]3([H])[C@H](O)[C@@H]5O)([O-])=O)([O-])=O)([H])O4.[NH4+].[NH4+]
分子式 C15H19N5O13P2?2NH4
分子量 575.4
溶解度 Soluble in water
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol , and treatment with this metabolite at 100 μM under heat stress conditions induces the release of oxytocin from the mouse hypothalamus.[9],[4]

Reference:
[1]. Lee, H.C., Walseth, T.F., Bratt, G.T., et al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+ -mobilizing activity. J. Biol. Chem. 264(3), 1608-1615 (1989).
[6]. Houtkooper, R.H., Cantó, C., Wanders, R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31(2), 194-223 (2010).
[8]. Lee, H.C. Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization. J. Biol. Chem. 287(38), 31633-31640 (2012).
[9]. Gul, R., Park, D.-R., Shawl, A.I., et al. Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) mediate Ca2+ signaling in cardiac hypertrophy induced by β-adrenergic stimulation. PLoS One 11(3), e0149125
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