Nifekalant (hydrochloride) (MS-551) 是一种 III 类抗心律失常药物，是一种 IKr 钾通道阻滞剂，IC50 为 10 μM。
| Cas No. | 130656-51-8 |
| 别名 | 盐酸尼非卡兰,MS-551 |
| Canonical SMILES | OCCN(CCNC1=CC(N(C)C(N1C)=O)=O)CCCC2=CC=C([N+]([O-])=O)C=C2.Cl |
| 分子式 | C19H27N5O5•HCl |
| 分子量 | 441.9 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM). |
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