SMI-481 是酵母磷脂酰肌醇转移蛋白 (PITP) Sec14 的选择性抑制剂。
| Cas No. |
432020-20-7 |
| Canonical SMILES |
FC1=C(N2CCN(C(C3=CC([N+]([O-])=O)=C(Cl)C=C3)=O)CC2)C=CC=C1 |
| 分子式 |
C17H15ClFN3O3 |
| 分子量 |
363.8 |
| 溶解度 |
DMF: 50 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.3 mg/ml |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 ?M, respectively). Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14. Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs. |
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