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Dermorphin(acetate)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dermorphin(acetate)图片
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议
10mg 电议
25mg 电议

半岛bd体育手机客户端 介绍
An opioid peptide
Canonical SMILES OC(C=C1)=CC=C1C[C@H](NC(CNC([C@@H](NC([C@@H](C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)CC3=CC=CC=C3)=O)=O)C(N4[C@H](C(N[C@@H](CO)C(N)=O)=O)CCC4)=O.CC(O)=O
分子式 C40H50N8O10.XC2H4O2
分子量 802.9
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Dermorphin is an opioid peptide originally isolated from the skin of South American frogs (Ph. sauvagei).1It binds to μ-opioid receptors (Ki= 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (Ki= 929 nM).In vivo, dermorphin (1.9 ?mol/kg, i.p.) inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats.2It inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons. Dermorphin (10-120 pmol/animal, i.c.v.) delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats.

1.Usenko, A.B., Emel'yanova, T.G., and MIasoedov, N.F.Dermorphins are natural opioids with an unique primary structure that determines their biological specificityBiol. Bull. Russ. Acad. Sci.29154-164(2002) 2.Melchiorri, P., and Negri, L.The dermorphin peptide familyGen. Pharmacol.27(7)1099-1107(1996)
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