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Esculin(hydrate)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Esculin(hydrate)图片
包装与价格：
包装 价格(元)
5 g 电议
10 g 电议
25 g 电议
50 g 电议

半岛bd体育手机客户端 介绍
A coumarin with antioxidant and anti-inflammatory activities
Canonical SMILES O=C1C=CC2=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C(O)C=C2O1.O
分子式 C15H16O9.XH2O
分子量 340.3
溶解度 DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Esculin is a coumarin that has been found inA. hippocastanumand has antioxidant and anti-inflammatory activities.1,2It reduces the size of gastric ulcers and decreases increases in the levels of malondialdehyde (MDA) and the activity of myeloperoxidase (MPO) and catalase in a mouse model of ethanol-induced ulcers when used at a dose of 25 mg/kg.1Esculin (20 mg/kg) decreases LPS-induced increases in the levels of TLR4, MyD88, IRAK4, and phosphorylated NF-?B in the lung, as well as levels of IL-1β, IL-6, and TNF-α in the bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.2

1.Rios, E.R., Rocha, N.F., Ven?ncio, E.T., et al.Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in miceChem. Biol. Interact.188(1)246-254(2010) 2.Tianzhu, Z., and Shumin, W.Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR/NF-κB pathwaysInflammation38(4)1529-1536(2015)
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