Voacamine 是一种吲哚生物碱，具有强大的大麻素 CB1 受体拮抗活性 。
| Cas No. |
3371-85-5 |
| 别名 |
老刺木胺 |
| Canonical SMILES |
C/C=C1CN(C)[C@@]2([H])CC3=C(NC4=C3C=CC=C4)[C@](C5=CC(NC6=C7CC[N@@](C8)[C@]9([H])[C@@]6(C(OC)=O)C[C@@]8([H])C[C@@H]9CC)=C7C=C5OC)([H])C[C@]\1([H])[C@]2([H])C(OC)=O |
| 分子式 |
C43H52N4O5 |
| 分子量 |
704.9 |
| 溶解度 |
DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Voacamine is an alkaloid originally isolated from Voacanga that has diverse biological activities. It is a cannabinoid receptor 1 (CB1) antagonist (IC50 = 41 nM). Voacamine (1-10 ?g/ml) time- and dose-dependently decreases survival of U2OS and multi-drug resistant U2OS (U2OS/DX) osteosarcoma cells and induces autophagy but not apoptosis. It also has antimalarial activity, inhibiting growth of P. falciparum in vitro at the trophozoite and schizont stages and reducing parasitemia in mice infected with P. yoelii when administered at doses of 2.5, 5, and 10 mg/kg. |
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