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Minodronic acid

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

180064-38-4

包装与价格：

半岛bd体育手机客户端介绍

Minodronic acid (YM-529) 是第三代二磷酸盐，直接或间接地阻止增殖，诱导细胞凋亡，并抑制各种类型的癌细胞的转移。Minodronic acid (YM-529) 是一种参与疼痛的嘌呤 P2X2/3 受体拮抗剂。

Cas No.	180064-38-4
别名	1-羟基-2-(咪唑并[1,2-A]吡啶-3-基)乙烷-1,1-双膦酸,YM-529
Canonical SMILES	OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=C2C=CC=CN21
分子式	C₉H₁₂N₂O₇P₂
分子量	322.15
溶解度	Water: 5 mg/mL (15.52 mM and warming); DMSO:< 1 mg/mL (insoluble or slightly soluble)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2]. P2X2/3[2] [1]. Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61. [2]. Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.