bpV(phen) (potassium hydrate) 是一种胰岛素模拟剂，是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂，对 PTEN 的 IC50 分别为 38 nM、343 nM 和 920 nM，PTP-β；和 PTP-1B，分别。
| Cas No. |
171202-16-7 |
| Canonical SMILES |
O=[V+3]123([O-][O-]2)([O-][O-]3)[N]4=C(C([N]1=CC=C5)=C5C=C6)C6=CC=C4.O.O.O.[K+] |
| 分子式 |
C12H8N2O5V?K+(H2O)3 |
| 分子量 |
404.3 |
| 溶解度 |
DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. |
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