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D-myo-Inositol-1,4,5-triphosphate(sodium salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
D-myo-Inositol-1,4,5-triphosphate(sodium salt)图片
CAS NO: 141611-10-1
包装与价格：
包装 价格(元)
500μg 电议
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
Primary intracellular IP3 receptor agonist
Cas No. 141611-10-1
别名 Ins(1,4,5)P3
化学名 D-myo-inositol-1,4,5-tris(hydrogen phosphate), trisodium salt
Canonical SMILES O[C@@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]
分子式 C6H12O15P3?3Na
分子量 486
溶解度 50mg/mL in PBS, pH 7.2
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate.[1][2] It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.[2][3]

Reference:
[1]. Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306(5938), 67-69 (1983).
[2]. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn. J. Pharmacol. 74(2), 125-137 (1997).
[3]. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36, 481-509 (1996).
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