NBI 31772 是有效的、非选择性的 IGFBP 抑制剂，Ki 值为 47 nM。
| Cas No. | 374620-70-9 |
| Canonical SMILES | OC1=C(O)C=C(C=C(C(O)=O)N=C2C(C3=CC=C(O)C(O)=C3)=O)C2=C1 |
| 分子式 | C17H11NO7 |
| 分子量 | 341.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 0.14 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | NBI 31772 is a nonpeptide ligand that releases insulin-like growth factor-1 (IGF-1) from its binding protein (IGFBP; Kis = 1-24 nM for the six human subtypes of IGFBP). As the released IGF-1 is biologically active, NBI 31772 is used to assess the role of IGF-1 in cells and animals, including in neuron survival, skeletal muscle regeneration, and glucose homeostasis. |
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