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IBS008738
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IBS008738图片
CAS NO: 385425-03-6
包装与价格：
包装 价格(元)
10mg 电议
25mg 电议

半岛bd体育手机客户端 介绍
IBS008738 是一种有效的 TAZ 激活剂。IBS008738 稳定C2C12 细胞中的 TAZ，增加未磷酸化的 TAZ 水平，增强 MyoD 与肌细胞生成素启动子的结合，上调 MyoD 依赖性基因转录，并与肌肉生长抑制素竞争。IBS008738 增强 C2C12 细胞的肌生成并促进肌肉损伤模型中的肌肉修复。
Cas No. 385425-03-6
分子式 C22H22N4O2
分子量 374.44
溶解度 DMSO : 50 mg/mL (133.53 mM; Need ultrasonic)
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

IBS008738 is a potentTAZactivator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model[1][2].

IBS008738 (0, 24, 48, 72 h) enhances TAZ expression, with a peak at 24 h[1].
IBS008738 (10 μM; 0, 24, 72 h) enhances mRNAs of myogenic markers but not of myofusion markers[1].
IBS008738 (10 μM; 24h) enhances mRNAs of IL-10 in C2C12 cells[2].

Western Blot Analysis[1]

Cell Line: C2C12 cells
Concentration:
Incubation Time: Treated for 0, 24, 48, 72 h under differentiation conditions after 24 h under growth conditions.
Result: Enhanced TAZ expression, with a peak at 24 h.

RT-PCR[1]

Cell Line: C2C12 cells
Concentration: 10 μM
Incubation Time: 0, 24, 72 h under differentiation
Result: Enhanced mRNAs of myogenic markers but not of myofusion markers.

IBS008738 (3 nmol) facilitates muscle repair in Cardiotoxin-injected muscles[1].
IBS008738 (30 μM, 100 μL) prevents Dexamethasone-induced muscle atrophy[1].
IBS008738 (100-μL volume of 30 μM; intramuscular injection; immediately and on day 2 after TBI) diminishes the expression of TNF α and IL-6 but increases that of IL-10 mRNAs in muscles of traumatic brain injury (TBI)[2].

Animal Model: Six-week-old female BALB/cByJ mice[1]
Dosage: 3 nmol (0.3 μL of 10 mM IBS008738 was diluted in 100 μL of PBS)
Administration: Injected into the tibialis anterior (TA) muscle of mice under anesthesia.
Result: Facilitated muscle repair in Cardiotoxin-injected muscles.
Animal Model: Six-week-old female BALB/cByJ mice[1]
Dosage: 30 μM (100 μL)
Administration: Injected into the tibialis anterior (TA) and gastrocnemius (GM) muscles on days 9, 11, and 13.
Result: Prevented Dexamethasone-induced muscle atrophy.

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