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FATP1-IN-1

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1431945-95-7

包装与价格：

半岛bd体育手机客户端介绍

FATP1-IN-1 是一种脂肪酸转运蛋白 1 (FATP1) 抑制剂。FATP1-IN-1 抑制重组人或小鼠 FATP1 acyl-CoA 合成酶活性，IC50 值分别为 0.046 μM和 0.60 μM。

Cas No.	1431945-95-7
分子式	C18H22FN5OS
分子量	375.46
溶解度	DMSO : 62.5 mg/mL (166.46 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	FATP1-IN-1 is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively[1]. FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC50 value of 0.22 μM without considering plasma protein binding. [1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565.