ERDRP-0519 - 半岛电竞官方网址

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ERDRP-0519

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1374006-96-8

包装与价格：

半岛bd体育手机客户端介绍

ERDRP-0519 是一种有效的，具有口服活性的麻疹病毒 (MeV) 小分子聚合酶 (polymerase) 抑制剂，可预防松鼠猴 (Saimiri sciureus) 的麻疹疾病。ERDRP-0519 以纳摩尔效力抑制麻疹病毒。

Cas No.	1374006-96-8
分子式	C23H30F3N5O4S
分子量	529.58
溶解度	DMSO : 100 mg/mL (188.83 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency.[1][2][3]. ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 ?M[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3]. A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50 mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2 h post-administration (Cmax=3.27 ?M)[3]. [1]. Wittwer K, et al. Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding. Nat Commun. 2021 Sep 2;12(1):5233.