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Acacetin
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Acacetin图片
CAS NO: 480-44-4
包装与价格：
包装 价格(元)
10mM (in 1mL DMSO) 电议
20mg 电议

半岛bd体育手机客户端 介绍
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种源自 Dendranthema morifolium 的具有口服活性的类黄酮。
Cas No. 480-44-4
别名 金合欢素; 5,7-Dihydroxy-4'-methoxyflavone
化学名 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
Canonical SMILES COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
分子式 C16H12O5
分子量 284.26
溶解度 ≥ 10.65mg/mL in DMSO
储存条件 Store at -20℃
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly suppressed the photoreceptor collapse. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) inhibited the generation of the APP-CTF by affecting APP cleavage. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) prolongs lifespan of significantly in the dose dependent manner[1].

References:
[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127.
[2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.
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