m-PEG9-NHS ester 是一种基于 PEG 的 PROTAC linker，用于 PROTAC 合成。
| Cas No. |
1316189-13-5 |
| 分子式 |
C24H43NO13 |
| 分子量 |
553.6 |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
m-PEG9-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Alexander Chucholowski, et al. Cyclodextrin conjugates. WO2010017328A2.
[2]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1. |
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