m-PEG8-C10-phosphonic acid 是一种 PROTAC linker,属于 PEG 类。m-PEG8-C10-phosphonic acid 可用于合成一系列 PROTAC 分子。
Cas No. |
2093153-86-5 |
分子式 |
C27H57O11P |
分子量 |
588.71 |
储存条件 |
Store at -20°C |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
m-PEG8-C10-phosphonic acid is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. |