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GNE 9278

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

901230-11-3

包装与价格：

半岛bd体育手机客户端介绍

Positive allosteric modulator of NMDA receptors; acts in transmembrane domain

Cas No.	901230-11-3
Canonical SMILES	OC(N1C2=NC(CCC)=N1)=C(C(C)=N2)N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O
分子式	C₂₁H₂₇N₅O₃S
分子量	429.54
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine. Wang et al (2017) A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 121 204 PMID:28457974