(2R/S)-6-PNG (6-Prenylnaringenin) 是一种有效且可逆的 Cav3.2 T 型 Ca2+ 通道 (T-channels) 阻滞剂。
Cas No. |
68682-01-9 |
别名 |
6-Prenylnaringenin |
Canonical SMILES |
C/C(C)=C\CC1=C(C=C2OC(C3=CC=C(C=C3)O)CC(C2=C1O)=O)O |
分子式 |
C20H20O5 |
分子量 |
340.37 |
溶解度 |
Soluble in DMSO |
储存条件 |
Store at -20°C |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
Cav3.2 (T-type) Ca2+ channel blocker (IC50 = 991 nM). Suppresses neuropathic allodynia in mouse pain models. Sekiguchi et al (2018) Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology 138 232 PMID:29913186 |