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Cedazuridine
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cedazuridine图片
CAS NO: 1141397-80-9
包装与价格：
包装 价格(元)
10mg 电议
25mg 电议

半岛bd体育手机客户端 介绍
Cedazuridine (E7727) (Compound 7a) 是一种具有口服活性的胞苷脱氨酶 (CDA) 抑制剂，其 IC50 值为 0.4 μM。Cedazuridine 可用于癌症的研究。
Cas No. 1141397-80-9
别名 E7727
分子式 C9H14F2N2O5
分子量 268.21
溶解度 DMSO : 50 mg/mL (186.42 mM; ultrasonic and warming and heat to 60°C)
储存条件 4°C, protect from light
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

IC50: 0.4 μM (CDA)[1]

Cedazuridine (E7727) (Compound 7a) is an orally activecytidine deaminase (CDA)inhibitor with anIC50value of 0.4 μM. Cedazuridine can be used for cancer research[1].

Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, ) in growth inhibition of AML cell lines[2].

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].

Animal Model: Female NSGS mice, 6-8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2]
Dosage: 3 mg/kg
Administration: Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result: Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.
Animal Model: NSGS male mice[2]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result: Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.

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