生物活性

CB-5083是新型的，一流的，有效的生物可利用的p97抑制剂，可破坏细胞蛋白稳态并在固体和血液学模型中显示出抗肿瘤活性。

靶点信息

p97 AAA ATPase
11 nM

化学数据

目录号	A15827
作用机制	Inhibitor (抑制剂)
M. Wt	413.4
Formula	C24H23N5O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1542705-92-9
Synonyms	CB-5083, CB 5083
SMILES	CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N

溶解度

In vitro (25°C)	DMSO	74 mg/mL (178.97 mM)
	Water	Insoluble
	Ethanol	Warmed: 12 mg/mL (29.02 mM)
In vivo	0.5% CMC Na+5% Tween 80	28 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.19 mL	120.95 mL	241.9 mL
0.5 mM	4.84 mL	24.19 mL	48.38 mL
1 mM	2.42 mL	12.09 mL	24.19 mL
5 mM	0.48 mL	2.42 mL	4.84 mL

*The above data is based on the productmolecular weight 413.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.