生物活性

ETC-1002是一种新颖的，一流的可以降低LDL-C的小分子；肝AMP激活的蛋白激酶（AMPK）的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性（IC50 = 29 uM）。

靶点信息

AMPK

化学数据

目录号	A15815
作用机制	Inhibitor (抑制剂), Activator (激活剂)
M. Wt	344.49
Formula	C19H36O5
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	738606-46-7
Synonyms	ESP-55016, ETC1002, ETC 1002
SMILES	CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O

溶解度

In vitro	DMSO	61 mg/mL (177.07 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.03 mL	145.14 mL	290.28 mL
0.5 mM	5.81 mL	29.03 mL	58.06 mL
1 mM	2.9 mL	14.51 mL	29.03 mL
5 mM	0.58 mL	2.9 mL	5.81 mL

*The above data is based on the productmolecular weight 344.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.