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LH846
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LH846图片
CAS NO: 639052-78-1
包装与价格：
包装 价格(元)
5mg 电议
10mg 电议
25mg 电议
50mg 电议

半岛bd体育手机客户端 介绍
LH846 是 CKIδ 的选择性抑制剂，IC50 为 290 nM，对 CKIα 和 CKIε 的抑制作用较弱，IC50 分别为 2.5 μM 和 1.3 μM。
Cas No. 639052-78-1
化学名 (Z)-N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetimidic acid
Canonical SMILES CC1=CC(S2)=C(N=C2/N=C(O)/CC3=CC=CC=C3)C=C1Cl
分子式 C16H13ClN2OS
分子量 316.81
溶解度 DMF: 5 mg/mL,DMSO: 5 mg/mL
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

LH846 is an inhibitor of casein kinases with IC50 values of 290nM, 2.5μM and 1.3μM against CKIδ, CKIα and CKIε, respectively [1].

As a small inhibitor of casein kinase, LH846 is developed for the treatment of the diseases that have an underlying circadian disorder. LH846 is previously screened out from a cell-based assay using human U2OS cells. It affects the circadian rhythm and lengthens the period (10h) at concentration of 8μM. LH846 can inhibit the activity of CKIδ, CKIα and CKIε with IC50 values of 290nM, 2.5μM and 1.3μM, respectively. The specific target of it is CKIδ. When treated with a panel of about 50 kinases, LH846 exerts potent inhibition against CKIδ and less potent effects on CKIα and ROCK2. CK2 is not sensitive to LH846 [1].

References:
[1] Lee J W, Hirota T, Peters E C, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angewandte Chemie, 2011, 123(45): 10796-10799.
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