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Cefminox sodium
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cefminox sodium图片
CAS NO: 75498-96-3
包装: 25mg
市场价: 810元

半岛bd体育手机客户端 介绍
Cefminoxsodium(MT-141)是一种半合成的头霉素，具有广谱的抗菌活性。Cefminoxsodium(MT-141)为前列环素受体(prostacyclinreceptor)和PPARγ的双重激动剂，能够上调cAMP的产生和PTEN的表达，抑制Akt/mTOR信号通路。Cefminoxsodium(MT-141)可抑制肺动脉高压。
Cas No. 75498-96-3
别名 头孢米诺钠; MT-141
Canonical SMILES O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(CSC[C@@H](N)C(O)=O)=O)C1=O)O[Na]
分子式 C16H20N7NaO7S3
分子量 541.56
溶解度 Water: 83.33 mg/mL (153.87 mM)
储存条件 4°C, protect from light
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity[1]. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ, upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension[2].

[1]. Inouye S, et al. In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins. Antimicrob Agents Chemother. 1984 Nov;26(5):722-9. [2]. Xia J, et al. Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats. Front Pharmacol. 2018 Feb 23;9:134.
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