T-91825 - 半岛电竞官方网址

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T-91825

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

189345-04-8

包装与价格：

半岛bd体育手机客户端介绍

T-91825 (PPI-0903M) 是一种 N-膦酰基型头孢菌素，是 TAK-599 的活性形式。T-91825 对革兰氏阳性菌和革兰氏阴性菌均有活性。

Cas No.	189345-04-8
别名	PPI-0903M
分子式	C₂₂H₂₀N₈O₅S₄
分子量	604.7
溶解度	DMSO : 100 mg/mL (165.37 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria[1][2]. PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL)[1].PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL[1]. AK-599 (20 mg/kg; s.c. three times a day for 2 days) decreases the bacterial cell counts in lungs more than 99.9% in a mouse pneumonia model caused by MRSA[2]. [1]. Sader HS, et, al. Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains. Antimicrob Agents Chemother. 2005 Aug;49(8):3501-12. [2]. Iizawa Y, et, al. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. J Infect Chemother. 2004 Jun;10(3):146-56.