| CAS NO: | 2143952-36-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 2143952-36-5 |
| Canonical SMILES | C[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@]([C@@H](COC=O)C)([H])CC4)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O |
| 分子式 | C25H38O4 |
| 分子量 | 402.6 |
| 溶解度 | Chloroform: 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2 1.MÜller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017) 2.KÖrner, A., Zhou, E., MÜller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019) |
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